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6 (1) 2016

Hypoglycemic effect of lotus (nelumbo nucifera gaertn.) Flower ethanolic extract on alloxan induced diabetes rat model


Author - Affiliation:
Ho Thi Huynh Thu - Ho Chi Minh City Open University , Vietnam
Phan Thi Thanh Xuan - Ho Chi Minh City Open University , Vietnam
Nguyen Thi Thuy Hang - Ho Chi Minh City Open University , Vietnam
Nguyen Nhut Vu - Ho Chi Minh City Open University , Vietnam
Trinh Huu Phuoc - Ho Chi Minh City Open University , Vietnam
Corresponding author: Ho Thi Huynh Thu - trinhhuuphuoc.ou@gmail.com

Abstract
The current study was purposed to evaluate an acute toxicity and effects of lotus (Nulumbo nucifera Gaertn.) flower ethanolic extract (LFEE) on alloxan induced diabetic rats. In vivo acute toxicity study of LFEE was carried out via the guideline of the testing of Chemicals (OECD) by oral administration at limit test of 2000 mg/Kg and 5000 mg/Kg, the results showed that, LD50 was greater than the limit dose at 5000 mg/Kg. The various dosages, including 150 and 200 mg/Kg, were enrolled in current study to evaluate its effect on fasting blood glucose reduction. The results revealed that LFEE had hypoglycemic activity, no signs and disorder symptoms were observed in the period of oral administration. Furthermore, the extract at a dose of 150 mg/Kg showed the good effect on reducing of fasting blood glucose. These findings indicated that LFEE had non acute toxicity and hypoglycemic activities, in future, alternative beneficial products in a treatment of diabetes.

Keywords
Nelumbo nucifera Gaertn; acute toxicity; diabetic rats; alloxan; LFEE.

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References

Abd El Sattar El Batran, S., El-Gengaihi S, E. , El Shabrawy, O. A. (2006). Some toxicological studies of Momordica charantia L. on albino rats in normal and alloxan diabetic rats. J Ethnopharmacol. 108(2), 236-42.


American Diabetes Association. (2014). Diagnosis and classification of diabetes mellitus. Diabetes Care., Suppl 1:S81-90.


Bandawane D, Juvekar A, Juvekar M. (2011). Antidiabetic and antihyperlipidemic effect of Alstonia scholaris Linn bark in streptozotocin Induced diabetic rats. Indian J Pharm Educ Res., 45(2), 114-120


International Diabetes Federation, http://www.idf.org/membership/wp/vietnam.


Kumar, S., Kumar, S., Prakash, O. M. (2012). Antidiabetic and hypolipidemic activities of Kigelia pinnata flowers extract in streptozotocin induced diabetic rats. Asian Pac J Trop Biomed. 2(7), 543-546


OCED Guidelines for the testing of Chemicals. http://www.oecd-ilibrary.org/environment/oecdguidelines-for-the-testing-of-chemicals-section-4-health-effects_20745788


Ono, Y., Hattor,i E., Fukaya, Y., Imai, S., Ohizumi, Y. (2006). Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats. J Ethnopharmacol., 106(2), 238-4.


Sakuljaitrong, S., Buddhakala, N., Chomko, Sanong., Talubmook, C. (2013). Effects of Flower extract from Lotus (Nelumbo nucifera) on hypoglycemic and hypolipidemic in streptozotocin-induced diabetic rats. IJSER., 4(7), 1441-1446.




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