Hepatitis B virus (HBV) genotype and its correlation with Hepatocellular carcinoma

Abstract

Hepatitis B is a viral disease caused by Hepatitis B Virus (HBV), which could cause both acute and chronic infection. HBV infection have been considered as the most common high risk factor that cause cirrhosis and subsequent development of Hepatocellular (HCC) worldwide. Even though Hepatitis B vaccine was found to be generally safe for two decades, however, HBV infection continues to be a major public health worldwide with the death raising from 600.000 to 1 million cases. Many risk factors, including HBV genotypes, have been proved to be associated to the chronic development and, then development of HCC. Current review was carried out to summarize the properties and prevalence of HBV genotypes, based on Vietnamese population, in order to highlight characteristic of HBV infection, simultaneously analyzed the correlation between HBV genotypes and other high risk factor related to HCC development.