Mini review: Micro RNA in nasopharyngeal carcinoma

Authors

  • Lao Duc Thuan
    Ho Chi Minh City Open University, VN
  • Nguyen Hoang Anh Tuan
    University of Science, Vietnam National University Ho Chi Minh City, VN
  • Nguyen Van Truong
    Ho Chi Minh City International University, Vietnam National University HCMC, VN
  • Nguyen Huu Dung
    Cho Ray Hospital, VN
  • Le Huyen Ai Thuy
    Ho Chi Minh City Open University, VN

Keywords:

miRNA; nasopharyngeal carcinoma; biomarkers; therapeutic agents

Abstract

Nasopharyngeal carcinoma (NPC) is a highly invasive and malignant tumor of the nasopharynx, the uppermost region of the pharynx, gravitating toward Southeast Asia, especially Vietnam. The etiology of NPC is suggested to be involved to several genetic susceptibility and environmental factors. miRNAs (microRNA), the short non-coding RNA molecular, have been reported that played important roles, as oncogene and/or tumor suppressor gene, in progression and development of NPC. In this review, we summarized the role of miRNAs in NPC and their potential use as biomarkers for early prognosis and diagnosis of NPC as well as therapeutic agent of NPC in future.

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References

Büssing, I., Slack, F. J., Grosshans, H. (2008). let-7 microRNAs in development, stem cells and cancer. J Cancer Res Clin Oncol. 137(3):415-22.

Chan, J. Y., Gao, W., Ho, W. K., Wei, W. I., Wong, T. S. (2012). Overexpression of EpsteinBarr virus-encoded microRNA-BART7 in undifferentiated nasopharyngeal carcinoma. Anticancer Res. 32(8):3201-10.

Chen, X., Ba, Y., Ma, L., Cai, X., Yin, Y., Wang, K., Guo, J., Zhang, Y., Chen, J., Guo, X., Li, Q., Li, X., Wang, W., Zhang, Y., Wang, J., Jiang, X., Xiang, Y., Xu, C., Zheng, P., Zhang, J., Li, R., Zhang, H., Shang, X., Gong, T., Ning, G., Wang, J., Zen, K., Zhang, J., Zhang, C. Y. (2008). Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 18(10):997-1006.

Chuang, J. C., Jones, P. A. (2007). Epigenetics and microRNAs. Pediatr Res., 61(5 Pt 2): 24R-29R.

Cortez, M. A., Bueso-Ramos, C., Ferdin, J., Lopez-Berestein, G., Sood, A. K., Calin, G. A. (2011). MicroRNAs in body fluids--the mix of hormones and biomarkers. Nat Rev Clin Oncol. 8(8):467-77.

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Received: 04-06-2020
Accepted: 04-06-2020
Published: 31-03-2016

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How to Cite

Thuan, L. D., Tuan, N. H. A., Truong, N. V., Dung, N. H., & Thuy, L. H. A. (2016). Mini review: Micro RNA in nasopharyngeal carcinoma. HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY, 6(1), 35–42. Retrieved from https://journalofscience.ou.edu.vn/index.php/tech-en/article/view/403