Screening of the matrix metalloproteinase inhibitory activity on extracts from Cordyceps neovolkiana DL0004 and Cordyceps takaomontana DL0038A fungi

Authors

  • Nguyen Nguyet Hong
    University of Science, Vietnam National University HCMC; Management Board of Agricultural Hi-Tech Park, VN
  • Cao Ha Tim
    University of Science, Vietnam National University HCMC, VN
  • Nguyen Chi Dung
    Graduate University of Science and Technology, Vietnam Academy of Science and Technology; Institute of Tropical Biology, Vietnam Academy of Science and Technology; Management Board of Agricultural Hi-Tech Park, VN
  • Dinh Minh Hiep
    Management Board of Agricultural Hi-Tech Park, VN
  • Ngo Ke Suong
    Institute of Tropical Biology, Vietnam Academy of Science and Technology, VN

DOI:

10.46223/HCMCOUJS.tech.en.10.1.361.2020

Keywords:

C. neovolkiana; C. takaomontana; metastasis; MMP

Abstract

Matrix metalloproteinases (MMPs) are endopeptidases, they are involved in tumor growth, and the processes of invasion and metastasis. Cordyceps spp. were recorded to have the anticancer potential. In previous studies, extracts from Cordyceps neovolkiana strain DL0004 and Cordyceps takaomontana strain DL0038A were capable of cytotoxic activity against MCF-7 and Jurkat cell lines. In this study, 26 extracts were prepared from biomasses and fruit bodies of C. neovolkiana DL0004 and C. takaomontana DL0038A, then proceed to screen for MMP inhibition assay by concentration ranges of 2000 µg/mL, 200 µg/mL, 20 µg/mL. The results showed that the CPS extract of the fruit body of the C. neovolkiana DL0004 had the highest activity in MMP inhibition with 84.27 ± 4.59% at 2000 µg/mL. The results were achievement for further studies of metastatic inhibition activities of Cordyceps extracts.

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References

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Received: 04-06-2020
Accepted: 04-06-2020
Published: 01-03-2020

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How to Cite

Hong, N. N., Tim, C. H., Dung, N. C., Hiep, D. M., & Suong, N. K. (2020). Screening of the matrix metalloproteinase inhibitory activity on extracts from Cordyceps neovolkiana DL0004 and Cordyceps takaomontana DL0038A fungi. HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY, 10(1), 65–71. https://doi.org/10.46223/HCMCOUJS.tech.en.10.1.361.2020

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Copyright (c) 2020 Nguyen Nguyet Hong; Cao Ha Tim; Nguyen Chi Dung; Dinh Minh Hiep; Ngo Ke Suong

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.