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10 (1) 2020

Screening of the matrix metalloproteinase inhibitory activity on extracts from Cordyceps neovolkiana DL0004 and Cordyceps takaomontana DL0038A fungi


Author - Affiliation:
Nguyen Nguyet Hong - University of Science, Vietnam National University HCMC; Management Board of Agricultural Hi-Tech Park , Vietnam
Cao Ha Tim - University of Science, Vietnam National University HCMC , Vietnam
Nguyen Chi Dung - Graduate University of Science and Technology, Vietnam Academy of Science and Technology; Institute of Tropical Biology, Vietnam Academy of Science and Technology; Management Board of Agricultural Hi-Tech Park , Vietnam
Dinh Minh Hiep - Management Board of Agricultural Hi-Tech Park , Vietnam
Ngo Ke Suong - Institute of Tropical Biology, Vietnam Academy of Science and Technology , Vietnam
Corresponding author: Nguyen Nguyet Hong - hong.ahtp@gmail.com

Abstract
Matrix metalloproteinases (MMPs) are endopeptidases, they are involved in tumor growth, and the processes of invasion and metastasis. Cordyceps spp. were recorded to have the anticancer potential. In previous studies, extracts from Cordyceps neovolkiana strain DL0004 and Cordyceps takaomontana strain DL0038A were capable of cytotoxic activity against MCF-7 and Jurkat cell lines. In this study, 26 extracts were prepared from biomasses and fruit bodies of C. neovolkiana DL0004 and C. takaomontana DL0038A, then proceed to screen for MMP inhibition assay by concentration ranges of 2000 µg/mL, 200 µg/mL, 20 µg/mL. The results showed that the CPS extract of the fruit body of the C. neovolkiana DL0004 had the highest activity in MMP inhibition with 84.27 ± 4.59% at 2000 µg/mL. The results were achievement for further studies of metastatic inhibition activities of Cordyceps extracts.

Keywords
C. neovolkiana; C. takaomontana; metastasis; MMP

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Cite this paper as:

Nguyen, N. H., Cao, H. T., Nguyen, C. D., Dinh, M. H., & Ngo, K. S. (2020). Screening of the matrix metalloproteinase inhibitory activity on extracts from Cordyceps Neovolkiana DL0004 and Cordyceps Takaomontana DL0038A fungi. Ho Chi Minh City Open University Journal of Science – Engineering and Technology, 10(1), 51-56.


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DOI: https://doi.org/10.46223/HCMCOUJS.tech.en.10.1.361.2020
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