The Microrna 29 family and its regulation

Authors

DOI:

10.46223/HCMCOUJS.tech.en.8.1.332.2018

Keywords:

growth factors; microRNAs; MiR-29 family; transcription factors

Abstract

Since miRNAs have broad effects on tissue homeostasis, and disease development, it is particularly interesting to work out how miRNAs themselves are being regulated. Such data could provide crucial information for further understanding the mechanism underlying disease development and for being able to manipulate these miRNAs therapeutically. Generally, the expression of miRNAs can be regulated transcriptionally, epigenetically, or controlled by different stimuli e.g. cytokines and growth factors. In review, just transcription factors, cytokines, and growth factors controlling the miR-29 family expression in human diseases were for the first time investigated.

Downloads

Download data is not yet available.

References

Ambros, V. (2004). The functions of animal microRNAs. Nature, 431(7006), 350-355.

Amodio, N., Di Martino, M. T., Foresta, U., Leone, E., Lionetti, M., Leotta, M., ... Tassone, P. (2012). miR-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop with the transcription factor Sp1. Cell Death Disease, 3. doi:10.1038/cddis.2012.175

Avasarala, S., Van Scoyk, M., Wang, J., Sechler, M., Vandervest, K., Brzezinski, C., … Winn, R. A. (2013). hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression. Biology Open, 2(7), 675-685. doi:10.1242/bio.20134507

Bartel, D. (2004). MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell, 116(2), 281-297.

Bartel, D. (2009). MicroRNAs: Target recognition and regulatory functions. Cell, 136(2), 215-233.

Downloads

Received: 03-06-2020
Accepted: 03-06-2020
Published: 17-08-2018

Statistics Views

Abstract: 341
PDF: 219
Crossref
Scopus
Google Scholar
Europe PMC

How to Cite

Linh, L. T. T. (2018). The Microrna 29 family and its regulation. HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY, 8(1), 18–27. https://doi.org/10.46223/HCMCOUJS.tech.en.8.1.332.2018

License

Copyright (c) 2018 Le Thi Truc Linh

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.